ALERT

Serious adverse effects resulting from the treatment with thalidomide prompted modern drug legislation more than 40 years ago. Post-marketing spontaneous reporting systems for suspected adverse drug reactions (ADRs) have been a cornerstone to detect safety signals in pharmacovigilance. It has become evident that adverse effects of drugs may be detected too late, when millions of persons have already been exposed.

In this project, an alternative approach for the detection of ADR signals will be developed. Rather than relying on the physician's capability and willingness to recognize and report suspected ADRs, the system will systematically calculate the occurrence of disease (potentially ADRs) during specific drug use based on data available in electronic patient records. In this project, electronic health records (EHRs) of over 30 million patients from several European countries will be available. In an environment where rapid signal detection is feasible, rapid signal assessment is equally important. To rapidly assess signals, a number of resources will be used to substantiate the signals: causal reasoning based on information in the EHRs, semantic mining of the biomedical literature, and computational analysis of biological and chemical information (drugs, targets, anti-targets, SNPs, pathways, etc.).

The overall objective of this project is the design, development and validation of a computerized system that exploits data from electronic healthcare records and biomedical databases for the early detection of adverse drug reactions. The ALERT system will generate signals using data and text mining, epidemiological and other computational techniques, and subsequently substantiate these signals in the light of current knowledge of biological mechanisms and in silico prediction capabilities. The system should be able to detect signals better and faster than spontaneous reporting systems and should allow for identification of subpopulations at higher risk for ADRs.

For further information, please visit:

Project co-ordinator:
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

Partners:

  • SOCIETA SERVIZI TELEMATICI SRL
  • UNIVERSIDADE DE AVEIRO
  • THE UNIVERSITY OF NOTTINGHAM
  • PHARMO COOPERATIE UA
  • AARHUS UNIVERSITETSHOSPITAL, AARHUS SYGEHUS
  • UNIVERSIDADE DE SANTIAGO DE COMPOSTELA
  • UNIVERSITAT POMPEU FABRA
  • IRCCS CENTRO NEUROLESI BONINO PULEJO
  • FUNDACIO IMIM
  • LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE
  • ASTRAZENECA AB
  • UNIVERSITE VICTOR SEGALEN BORDEAUX II
  • AGENZIA REGIONALE DI SANITA
  • UNIVERSITA DEGLI STUDI DI MILANO - BICOCCA

Timetable: from 02/2008 – to 07/2011

Total cost: € 5.880.600

EC funding: € 4.500.000

Programme Acronym: FP7-ICT

Subprogramme Area: Advanced ICT for risk assessment and patient safety

Contract type: Collaborative project (generic)

Related news article:

Most Popular Now

Artificial Intelligence Detects a New Cl…

Many mutations in DNA that contribute to disease are not in actual genes but instead lie in the 99% of the genome once considered "junk." Even though scientists have recently...

Essen University Medicine and Siemens He…

The Essen University Medicine, Germany's leading hospital company for digitalized medicine, and Siemens Healthineers, a world-leading medical technology company, plan to work together to develop the hospital of the future...

Final Cohort Selected For Pioneering Dig…

Propel@YH has announced the six start-ups to participate in its inaugural digital health accelerator programme, aimed at navigating the complex healthcare landscape and building an NHS-relevant business case. The Leeds-based...

New Kid on the Block: The Doctrina Acade…

The Doctrina Academy is a new service, developed by Doctrina, a video e-learning platform that reaches over 1,000,000 healthcare professionals (HCPs) from around the globe, helping them to switch ...

Efficacy and SilverCloud Health Supports…

A leading mental health service is using the digital mental health platform developed by SilverCloud Health to support a confidential NHS service for GPs in England. London-based Efficacy is offering...

Gloucestershire Hospitals to Deliver EPR…

Gloucestershire Hospitals NHS Foundation Trust is moving to a 'clinical wrap' strategy to deliver an electronic patient record (EPR) and achieve the highest levels of digital maturity within five-years. The...

Mobile Phone App Designed to Boost Physi…

Activity trackers and mobile phone apps are all the rage, but do they really help users increase and maintain physical activity? A new study has found that one mobile phone...

Application Period for an International …

The Master of Science (M.Sc.)in Medical Informatics (MMI) at European Campus Rottal-Inn (ECRI) in Pfarrkirchen - a branch of the Deggendorf University of Applied Sciences (THD - Technische Hochschule Deggendorf)...

NHS Prescribing is Back in the Spotlight…

Opinion Article by Dr Simon Hendricks, Product Innovation Manager and Clinical Strategy Lead, FDB (First Databank) Political will for better and safer prescribing in the NHS has fast gained momentum in...

Sectra to Provide Large Centralized Regi…

International medical imaging IT and cybersecurity company Sectra (STO: SECT B) has signed a five-year contract with North Tees and Hartlepool NHS Foundation Trust for the delivery of a regional...

IMI to Boost Patient Involvement in its …

The Innovative Medicines Initiative (IMI) is creating a 'pool' of patient experts to strengthen the role and voice of patients in IMI activities at both strategic and operational levels. IMI...