ALERT

Serious adverse effects resulting from the treatment with thalidomide prompted modern drug legislation more than 40 years ago. Post-marketing spontaneous reporting systems for suspected adverse drug reactions (ADRs) have been a cornerstone to detect safety signals in pharmacovigilance. It has become evident that adverse effects of drugs may be detected too late, when millions of persons have already been exposed.

In this project, an alternative approach for the detection of ADR signals will be developed. Rather than relying on the physician's capability and willingness to recognize and report suspected ADRs, the system will systematically calculate the occurrence of disease (potentially ADRs) during specific drug use based on data available in electronic patient records. In this project, electronic health records (EHRs) of over 30 million patients from several European countries will be available. In an environment where rapid signal detection is feasible, rapid signal assessment is equally important. To rapidly assess signals, a number of resources will be used to substantiate the signals: causal reasoning based on information in the EHRs, semantic mining of the biomedical literature, and computational analysis of biological and chemical information (drugs, targets, anti-targets, SNPs, pathways, etc.).

The overall objective of this project is the design, development and validation of a computerized system that exploits data from electronic healthcare records and biomedical databases for the early detection of adverse drug reactions. The ALERT system will generate signals using data and text mining, epidemiological and other computational techniques, and subsequently substantiate these signals in the light of current knowledge of biological mechanisms and in silico prediction capabilities. The system should be able to detect signals better and faster than spontaneous reporting systems and should allow for identification of subpopulations at higher risk for ADRs.

For further information, please visit:

Project co-ordinator:
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

Partners:

  • SOCIETA SERVIZI TELEMATICI SRL
  • UNIVERSIDADE DE AVEIRO
  • THE UNIVERSITY OF NOTTINGHAM
  • PHARMO COOPERATIE UA
  • AARHUS UNIVERSITETSHOSPITAL, AARHUS SYGEHUS
  • UNIVERSIDADE DE SANTIAGO DE COMPOSTELA
  • UNIVERSITAT POMPEU FABRA
  • IRCCS CENTRO NEUROLESI BONINO PULEJO
  • FUNDACIO IMIM
  • LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE
  • ASTRAZENECA AB
  • UNIVERSITE VICTOR SEGALEN BORDEAUX II
  • AGENZIA REGIONALE DI SANITA
  • UNIVERSITA DEGLI STUDI DI MILANO - BICOCCA

Timetable: from 02/2008 – to 07/2011

Total cost: € 5.880.600

EC funding: € 4.500.000

Programme Acronym: FP7-ICT

Subprogramme Area: Advanced ICT for risk assessment and patient safety

Contract type: Collaborative project (generic)

Related news article:

Most Popular Now

mHealth as Effective as Clinic-Based Int…

A mobile health (mHealth) intervention was found to be as effective as a clinic-based group intervention for people with serious mental illness in a new study published online in Psychiatric...

Mobile Health Technology can Potentially…

Mobile health technology has the potential to transform the way we prevent and manage heart disease, but there are unanswered questions about how to optimize this technology and maintain engagement...

New Computational Tool could Help Optimi…

Scientists have developed a novel computational approach that incorporates individual patients' brain activity to calculate optimal, personalized brain stimulation treatment for Alzheimer's disease. Lazaro Sanchez-Rodriguez of the University of Calgary...

First Call for Science and Technology at…

Participate in the first ever ESC Digital Health Call for Technology, for the chance to present your innovations, your technology or your products at ESC Congress 2018 in front of...

Siemens Healthineers Assists Swiss Post …

To expand its portfolio in the area of eHealth, Swiss Post will make use of the Siemens Healthineers eHealth Solutions(1) in the future. The eHealth solution offered by Swiss Post...

Philips Expands its Therapeutic Care Bus…

Royal Philips (NYSE: PHG, AEX: PHIA), a global leader in health technology, announced that it has acquired Remote Diagnostic Technologies (RDT), a UK-based leading innovator of advanced solutions for the...

Joined-Up Health & Care Conference M…

InterSystems, a global leader in health information technology, will be celebrating a double anniversary at its annual Joined-Up Health & Care conference. This year’s event at The Belfry, Sutton Coldfield...

Ingestible 'Bacteria on a Chip' could He…

MIT researchers have built an ingestible sensor equipped with genetically engineered bacteria that can diagnose bleeding in the stomach or other gastrointestinal problems. This "bacteria-on-a-chip" approach combines sensors made from...

FDA Takes New Steps to Advance Digital H…

Today, the FDA is opening a docket to solicit feedback on important provisions of the 21st Century Cures Act ("Cures Act"). The Cures Act amended the Federal Food, Drug, and...

Mobile App for Autism Screening Yields U…

A Duke study of an iPhone app to screen young children for signs of autism has found that the app is easy to use, welcomed by caregivers and good at...

Open Call MSCA-IF-2018: Individual Fello…

The goal of the Individual Fellowships is to enhance the creative and innovative potential of experienced researchers, wishing to diversify their individual competence in terms of skill acquisition through advanced...

Lexmark Partners with NHS Shared Busines…

Lexmark, a global imaging solutions leader, today announced a partnership with NHS Shared Business Services (NHS SBS) to enable the public sector to utilise Lexmark technology to support their aim...