preDiCT

Many drugs fail to reach the market because of side effects on the heart. The principal objective of this proposal is to create an advanced computational technology for in silico assessment of the efficacy and safety of specific drugs [ICT-2007.5.3(c) (3)], i.e. an open environment comprising validated computational models, tools and numerical methods that will enable simulations of drug actions on the electrophysiology of the human heart.

Such simulations will involve modelling of drug interactions at the molecular and cellular level, will extend current technology to enable prediction of the effects of those interactions on the dynamics of the whole heart, and will lead to an understanding of how genetic factors can be used to assess patient-specific risk profiles. This requires a multi-level systems approach, based on multi-scale, multi-physics methods, including computations on adaptive spatial grids and multi-grid time integration. Computations on realistic models at appropriate spatial and temporal scales are currently not feasible, so we will investigate new algorithms and their implementation on high-performance platforms, including a new generation of petaflop computers, to achieve 'faster than real-time' simulation.

These tools form part of the infrastructure required to simulate the physiology of major organ systems, thereby contributing to the goal of creating the Virtual Physiological Human (VPH) [ICT-2007.5.3]. The balanced team in this project, including founders of the Human Physiome Project, has decades of experience in the experimental study and modelling of the electrophysiology and mechanics of the heart, while pharmaceutical industry partners bring deep understanding of the mechanisms of drug actions. The results will demonstrate the value of the VPH initiative to fundamental scientific understanding of the heart, with major economic and clinical impacts through accelerated drug development, approval and use.

For further information, please visit:
http://www.vph-predict.eu

Project co-ordinator:
The Chancellor, Master and Scholars of the University of Oxford

Partners:

  • F. Hoffmann-La Roche AG
  • Szegedi Tudományegyetem
  • Fujitsu Laboratories of Europe Limited
  • Glaxo Smithkline Research and Development
  • Universidad Politécnica de Valencia
  • Centro di Ricerca, Sviluppo e Studi Superiori in Sardegna
  • Novartis Pharma AG
  • Aureus Pharma SA

Timetable: from 06/2008 – to 05/2011

Total cost: € 5.545.692

EC funding: € 4.100.000

Programme Acronym: FP7-ICT

Subprogramme Area: Virtual physiological human

Contract type: Collaborative project (generic)


Related news article:

Most Popular Now

Augmented Reality Visor to Dramatically …

Employing new photonics technology, European scientists are developing a new Augmented Reality surgical visor in a bid to improve accuracy of interventions, showing anaesthetic and medical data while superimposing a...

Read more

Interactive Health Apps May Inspire Heal…

Just like real doctors and nurses, online health tools with good - but controlled - communication skills can promote healthier lifestyles, according to researchers. However, if their tone is conversational...

Read more

Call for Papers: EHB 2017 - IEEE Interna…

22 - 24 June 2017, Sinaia, Romania. The 6-th edition of the International Conference on e-Health and Bioengineering, EHB 2017, will take place in the city of Sinaia, Romania. This year...

Read more

UK and Italian Health Tech Firms to Help…

Data sharing ambitions set out in newly published sustainability and transformation plans (STPs) have been given a boost by a new strategic partnership between data management specialist Stalis and Italy's...

Read more

From Health Apps to Nursing Robots - A G…

25 - 27 April 2017, Berlin, Germany. Around the world the subject of e-Health is steadily gaining in importance, whether it involves electronic patient files, online video consultations or any of...

Read more

Philips Teams Up with German Startup One…

Royal Philips (NYSE: PHG, AEX: PHIA), a global leader in health technology, today announced a partnership agreement with German digital health company Onelife Health to jointly develop innovative connected health...

Read more

EU eHealth Competition 2017

The eHealth Competition is an initiative that rewards the best eHealth / mHealth solutions produced by European SMEs (Small and Medium Enterprises). Its objective is to support business success of...

Read more

Philips and LabPON Plan to Create World…

Royal Philips (NYSE: PHG, AEX: PHIA) and LabPON, the first clinical laboratory to transition to 100% histopathology digital diagnosis, have announced its plans to create a digital database of massive...

Read more

Virtual Reality Cognitive Training Game …

Greek researchers demonstrated the potential of a self-administered virtual supermarket cognitive training game for remotely detecting mild cognitive impairment (MCI), without the need for an examiner, among a sample of...

Read more

Technology Boost for Health and Social C…

Health and social care organisations aiming to be fully compliant with the government’s Personalised Health and Care 2020 plan, can now access electronic health record (EHR) and healthcare integration technologies...

Read more

Agfa HealthCare's Health Management Pla…

Agfa HealthCare announces today that its health management platform, including the XERO universal image viewer, has been selected to support the joint Radiotherapy Treatment Project of the Saolta University Health...

Read more

Philips Introduces Advanced Radiology So…

Royal Philips (NYSE: PHG, AEX: PHIA), a global leader in health technology, has unveiled new advanced radiology solutions at the 2017 European Congress of Radiology (ECR). In response to today's...

Read more
(HEALTH IT) SPACE - Take a look at who has just Joined