New FP7 eHealth Project - ALERT

A new EU-funded information and communication technology (ICT) project is tackling issues of safety in newly developed drugs. Over the next three and a half years, the ALERT (Early detection of adverse drug events by integrative mining of clinical records and biomedical knowledge) project partners will work on an innovative computer system for a better and faster detection of adverse drug reactions (ADRs).

Currently, so-called spontaneous reporting systems are used when side effects are discovered in a drug that is already on the market. Clinicians are responsible for recognising and reporting those side effects. "A number of recent, highly publicised drug safety issues showed that adverse effects of drugs may be detected too late, when millions of patients have already been exposed," the research consortium comments.

With the aim of improving this system, ALERT will analyse data from electronic healthcare records (EHRs) of over 30 million patients from the Netherlands, Denmark, UK, Spain and Italy, using a variety of computational techniques. Those techniques, including text mining and epidemiological computing, will help to retrieve information from the data and detect 'signals', such as combinations of drugs and suspected ADRs that require further investigation.

The focus of the ALERT project will be on side effects in children, as relatively little is known about them and children are particularly vulnerable. Moreover, the interdisciplinary research team will attempt to find a way to discriminate between signals that do indeed indicate an ADR and spurious signals, which might even result in withdrawal of a useful drug from the market. In order to make this distinction, the ALERT researchers will look for a biological explanation for each signal by comparing the side effect with up-to-date knowledge about biological mechanisms. The findings will then be further corroborated in computer simulations and models.

The project partners emphasise that this kind of analysis is a continuous process: "As more patient data become available and medical, biological and molecular knowledge expands, previous conclusions will need to be revisited. In order to deal with this constant process of revision, ALERT will focus on automated procedures as much as possible."

A total of 18 project partners from eight countries are involved in the ALERT project, which is coordinated by the Erasmus University Medical Centre Rotterdam, Netherlands. The project cost amounts to nearly €5.9 million, €4.5 million of which are covered by the EU's Seventh Framework Programme (FP7)

For further information, please visit:
Erasmus University Medical Centre Rotterdam
http://www.erasmusmc.nl/
IMIM Foundation (Fundació Institut Municipal d'Investigació Mèdica), Barcelona
http://www.imim.es/

Related article:
FP7 Projects: ALERT

Copyright ©European Communities, 2008
Neither the Office for Official Publications of the European Communities, nor any person acting on its behalf, is responsible for the use, which might be made of the attached information. The attached information is drawn from the Community R&D Information Service (CORDIS). The CORDIS services are carried on the CORDIS Host in Luxembourg - http://cordis.europa.eu. Access to CORDIS is currently available free-of-charge.

Most Popular Now

Using Artificial Intelligence to Predict…

Thyroid nodules are small lumps that form within the thyroid gland and are quite common in the general population, with a prevalence as high as 67%. The great majority of...

NHS Health Tech Team of the Year Named

A pioneering NHS trust has been recognised at the 2019 HTN Awards for its innovative work using InterSystems technology to help enhance care for hundreds of thousands of patients. North...

Philips and Klinikum Stuttgart Hospital …

Royal Philips (NYSE:PHG, AEX:PHIA), a global leader in health technology, and German Klinikum Stuttgart hospital, the largest provider in the region, announced they have signed a comprehensive 10-year innovation partnership...

Personalised and Powerful: UK to Lead Ne…

The UK will be transformed into a global hub for radiotherapy research, pioneering the use of the latest techniques such as FLASH radiotherapy and artificial intelligence, with a new £56...

Innovations for Tomorrow's Healthcare - …

18 - 21 November 2019, Düsseldorf, Germany. Groundbreaking innovations shape tomorrow's medical progress. At this year's MEDICA, visitors can find out what these exemplary innovations will be like in the here...

Siemens Healthineers Closes ECG Manageme…

Siemens Healthineers AG has completed the acquisition of a majority stake in ECG Management Consultants, a leading U.S. healthcare advisory firm, with an effective date of November 1, 2019. The...

SilverCloud Health Marks World Mental He…

More than 300,000 people suffering with mental health disorders such as anxiety and depression have now been treated through innovative digital therapy programmes developed as a result of a partnership...

Doctors Give Electronic Health Records a…

The transition to electronic health records (EHRs) was supposed to improve the quality and efficiency of healthcare for doctors and patients alike - but these technologies get an "F" rating...

AI Predicts which Pre-Malignant Breast L…

New research at Case Western Reserve University could help better determine which patients diagnosed with the pre-malignant breast cancer commonly as stage 0 are likely to progress to invasive breast...

Nuance and Microsoft Partner to Transfor…

Nuance Communications Inc. and Microsoft Corp. have joined forces to help transform healthcare delivery for a more sustainable future. Together, the companies will accelerate the delivery of ambient clinical intelligence...

MEDICA 2019 + COMPAMED 2019 Bring in ove…

18 - 21 November 2019, Düsseldorf, Germany. More dynamic, more digital and more networked than ever: the medical industry is taking strides into the future. If you want to be in...

Telehealth Effectively Diagnoses / Manag…

A recent study of 368 pregnant mothers, led by Bettina Cuneo, MD, director of perinatal cardiology and fetal cardiac telemedicine at Children's Hospital Colorado, found that fetal congenital heart disease...