SIMAP

SIMAP will develop a simulation model of the cancer related MAP-kinase pathway, integrating and analyzing data from various types of resources, which may assist in the development of better cancer treatment.

The completion of the human genome gave hope for a new age of medical understanding, but 4-5 years later costs of drug development are still rising and the success rate has not improved. Drugs that have already hit the market are found to have major side effects not perceived in the past and are often given to patients without discrimination on their likeliness to respond.

Large scale methodologies that thrive in recent years, allowed the industry and academia to gather more information on RNAs and proteins. However, the understanding of the molecular and cellular processes is still lacking, not to mention the connection to the clinical outcome. In order to fully use this data, a comprehensive integration and modelling effort is needed. A systematic rational hypothesis-driven research approach connecting all those levels of information is a much needed computational tool. This is the main goal of SIMAP project.

The ultimate goal of SIMAP is to develop a comprehensive simulation biochemical model of EGFRMAP kinase pathway in connection to cancer clinical information. SIMAP will:

  • Incorporate low-level biochemical modelling of individual molecules;
  • Simulate the behaviour of the pathway;
  • Add genomic and proteomic data;
  • Incorporate individual patients’ responses; and
  • Analyze sub population of responses in the context of the biochemical behaviour and genotype data

For further information, please visit:
http://www.simap-project.org

Project co-ordinator:
Compugen Ltd.

Partners:

  • Aureus Pharma, (FR)
  • Compugen Ltd., (IL)
  • Consejo Superior de Investigaciones Científicas, (ES)
  • Halevi Dweck & Co.Arttic Israel Company Ltd., (IL)
  • Fundacio Institut De Recerca De L'Hospital Universitari Vall D'Hebron, (ES)
  • Fondazione IRCCS Istituto Nazionale Dei Tumori, (IT)
  • The Max-Planck Institute for Infection Biology, (DE)
  • The University of Glasgow, (UK)
  • The Weizmann Institute of Science, (IL)

Timetable: from 01/06 – to 12/08

Total cost: € 4.464.201

EC funding: € 3.126.662

Instrument: STREP

Project Identifier: IST-2004-027265

Source: FP6 eHealth Portfolio of Projects

Most Popular Now

MSD Innovation Factory Selects 3 Compani…

Throughout the MSD Innovation Factory, MSD launched 7 health-related challenges to award the three most outstanding solutions. Blendarsys, Symptoma and Grupo Pulso are the winners out of 100 proposals. The...

Using Virtual Reality to Identify Brain …

Virtual reality is helping neuroscientists at the University of California, Davis, get new insight into how different brain areas assemble memories in context. In a study published Jan. 18 in...

People with Tetraplegia Gain Rapid Use o…

For a brain-computer interface (BCI) to be truly useful for a person with tetraplegia, it should be ready whenever it's needed, with minimal expert intervention, including the very first time...

East Lancashire Hospitals Chooses Cerner…

East Lancashire Hospitals NHS Trust (ELHT) has chosen global health information technology leader Cerner as its Preferred Supplier of a new clinical information system that will help to improve the...

Hamlyn Centre Announces Grant from Bill …

The Hamlyn Centre at Imperial College London today announces the award of a grant from the Bill & Melinda Gates Foundation, to accelerate research into new integrated technology systems for...

Philips Debuts Fully Integrated Suite o…

Royal Philips (NYSE: PHG, AEX: PHIA), a global leader in health technology, announced the launch of its next-generation Patient Monitoring solution in the U.S. The enterprise-wide system consists of bedside...

Liverpool Awards Contract to Docobo

One of the best-known users of telehealth in England has awarded a contract to Docobo to significantly expand its service over the next three years. NHS Liverpool Clinical Commissioning Group...

Augmented Reality System Lets Doctors Se…

New technology is bringing the power of augmented reality into clinical practice. The system, called ProjectDR, allows medical images such as CT scans and MRI data to be displayed directly...

Assessing Health Technology in the EU: C…

European Commission has put forward a proposal to boost cooperation amongst EU Member States for assessing health technology. Greater transparency will empower patients, by ensuring their access to information on...

ProEmpower Releases Call for Tenders to …

The ProEmpower procurers are looking for a diabetes management solution that will tackle the unmet needs in the current treatment of diabetes such as the fragmentation in today’s healthcare systems...

Biosensors Will Be Inexpensive, Do More…

When it comes to biometric sensors, human skin isn't an ally. It's an obstacle. The University of Cincinnati is developing cutting-edge methods to overcome this barrier without compromising the skin...