IMI Launches New Antimicrobial Resistance Accelerator Programme as Part of Latest Calls for Proposals

Innovative Medicines InitiativeA new Antimicrobial Resistance (AMR) Accelerator Programme is part of new Calls for proposals launched today by the Innovative Medicines Initiative (IMI). Of the other topics launched in the Calls, many address brain disorders (e.g. Alzheimer's disease, Parkinson's disease, Huntington's disease, major depression) and immune-mediated diseases (e.g. rheumatoid arthritis and lupus as well as inflammatory bowel diseases such as Crohn's and colitis, and skin diseases like dermatitis and psoriasis). Among other things, the topics aim to make clinical trials more patient-centric, contribute to medicines safety, and apply blockchain technologies to the drug development and health sectors.

The two Calls for proposals launched today (IMI2 - Calls 15 and 16) have a total budget of EUR 434 million. Around half of this comes from Horizon 2020, the EU's framework programme for research and innovation. The other half comes from EFPIA companies and IMI Associated Partners; these do not receive any funding from IMI but contribute to projects, mainly through 'in-kind' contributions (e.g. researchers' time).

Pierre Meulien, IMI Executive Director commented: "Our new Antimicrobial Resistance Accelerator programme represents a strategic, coordinated response to one of the biggest challenges facing the world today. Meanwhile the topics on digital health and the blockchain highlight IMI’s commitment to working with all sectors involved in healthcare."

Introducing the AMR Accelerator

The aim of the new IMI AMR Accelerator is to progress the development of new medicines to treat or even prevent resistant bacterial infections in Europe and worldwide. The programme comprises three pillars. A Capability Building Network will coordinate the programme and carry out research to strengthen the scientific basis in the AMR field, while the Tuberculosis Drug Development Network will work to accelerate the discovery of new combinations of drugs to treat TB. Finally, Portfolio Building Networks will support collaborative efforts to discover, develop and advance new and innovative agents to prevent or treat AMR. The scope of the AMR Accelerator is broad; under one structure, it will address many of the scientific challenges of AMR, and it will support the development of new ways to prevent AMR (including vaccines) and treatments (including new antibiotics). More broadly, the IMI AMR Accelerator also contributes to the European action plan on AMR, which includes a chapter on boosting research, development and innovation for AMR.

Research platforms for patient-centric drug development

Currently, clinical trials are generally carried out in silos and all too often, they are not patient friendly, making it hard to enrol enough patients. This topic aims to develop and disseminate reusable best practices, tools and guidelines for establishing multi-company platform trials capable of running patient-friendly clinical trials that test multiple treatments in parallel. The topic focuses on developing platform trial designs and protocols in four disease areas: major depressive disorder, tuberculosis, the liver disease non-alcoholic steatohepatitis (NASH), and neurofibromatosis. In the short term, the research platforms will speed up the enrolment of patients in clinical trials and increase the likelihood that participating patients are allocated a promising treatment instead of the placebo. In the longer term, this will help to accelerate medicines development.

Clinical trials go digital

Current clinical trial assessments are often based on subjective clinical scoring systems, which do not provide an accurate, detailed picture of a patient's condition. This topic aims to tackle this problem by identifying, assessing and validating digital technologies (e.g. wearable and home-based devices) that could reliably and sensitively measure patients' clinical conditions in their homes or as they go about their daily lives. The project will focus its efforts on technologies capable of monitoring patients with neurodegenerative disorders (namely Parkinson's disease and Huntington's disease) and inflammatory diseases (rheumatoid arthritis or lupus, and inflammatory bowel disease). The project will ultimately result in better clinical trials that provide more detailed data on patients' condition and also allow more patients to take part in clinical trials.

A better understanding of immune-mediated diseases

New biological treatments have provided relief for many patients with immune-mediated diseases. However, the treatments do not work for all patients. This topic aims to identify signatures in bodily fluids that could predict how a disease will progress and whether a patient's response to a treatment could change over time. The project will focus on inflammatory bowel disease (Crohn's disease and ulcerative colitis) and skin-related diseases (e.g. atopic dermatitis, cutaneous lupus, psoriasis). In the long term, the project will improve our understanding of these diseases, make it easier to identify patients whose disease is likely to progress, and lead to more tailored treatments.

Towards safer immune therapies

Certain treatments for cancers and immune diseases work by altering the immune system. However, a major challenge for researchers is identifying potential safety issues with these treatments early in drug development, before they are tested in humans. The goal of this topic is to deliver a range of tools that will enhance our ability to assess the safety of these immunomodulatory therapies. In the long term, this will help to deliver safer medicines for patients and also contribute to the ‘3Rs’ (i.e. the drive to replace, reduce and refine the use of animals in research).

Joining the dots on brain disorders

Synapses are the junctions between nerve cells, and are responsible for ensuring nerve signals are correctly transmitted from one nerve cell to another. Synapse malfunctions have been identified in a number of brain disorders, but questions about their role in disease remain. This topic aims to study the synapses in detail; to understand the extent to which synapse problems are a cause of brain disorders, and whether this information could be used in drug development. The topic also aims to find out if they synapse problems found in different neurodegenerative and psychiatric diseases (e.g. Alzheimer’s, Parkinson’s, major depression, and schizophrenia) have the same underlying cause or not. The project results will help to speed up the development of more effective treatments for these diseases.

Bringing the blockchain into healthcare

This topic aims to establish a common blockchain ecosystem for pharmaceutical development, manufacturing and distribution. By bringing together all parties, including patients, healthcare providers and health authorities, it will establish an agreed framework and reference implementation that addresses data integrity, security and privacy as well as regulatory compliance and efficiency. This framework will act as an integration layer linking underlying blockchain technologies with specific business applications in areas such as the supply chain, clinical development, and health data. Long-term impacts of the project will be greater trust between all participants in the sector and the more efficient use of resources.

About IMI2 - Call 15

IMI2 - Call 15 is a standard two-stage Call for proposals with the following topics:
  • Integrated research platforms enabling patient-centric drug development
  • Blockchain enabled healthcare
  • Microenvironment imposed signatures in tissue and liquid biopsies in immune-mediated diseases
  • Emerging translational safety technologies and tools for interrogating human immuno-biology
  • Development and validation of translational platforms in support of synaptopathy drug discovery
  • Digital endpoints in neurodegenerative and immune-mediated diseases
Topics under the IMI2 Antimicrobial Resistance (AMR) Accelerator programme:
  • AMR Accelerator programme Pillar A: Capability Building Network to accelerate and validate scientific discoveries
  • AMR Accelerator programme Pillar B: Tuberculosis drug development network to accelerate and validate scientific discoveries and advance the R&D pipeline of new and innovative agents to address the global tuberculosis epidemic

Deadline for short proposals: 24 October 2018

For further information, please visit:
https://www.imi.europa.eu/apply-funding/open-calls/imi2-call-15

About IMI2 - Call 16

IMI2 - Call 16 is a single-stage Call for proposals dedicated to Pillar C of the AMR Accelerator programme 'Portfolio Building Networks to advance the R&D pipeline of new and innovative agents to address AMR'

Deadline for proposals: 24 October 2018

For further information, please visit:
https://www.imi.europa.eu/apply-funding/open-calls/imi2-call-16

About the Innovative Medicines Initiative

The Innovative Medicines Initiative (IMI) is working to improve health by speeding up the development of, and patient access to, the next generation of medicines, particularly in areas where there is an unmet medical or social need. It does this by facilitating collaboration between the key players involved in healthcare research, including universities, pharmaceutical companies, other companies active in healthcare research, small and medium-sized enterprises (SMEs), patient organisations, and medicines regulators. This approach has proven highly successful, and IMI projects are delivering exciting results that are helping to advance the development of urgently-needed new treatments in diverse areas.

IMI is a partnership between the European Union and the European pharmaceutical industry, represented by the European Federation of Pharmaceutical Industries and Associations (EFPIA). Through the IMI2 programme, IMI has a budget of €3.3 billion for the period 2014-2020. Half of this comes from the EU's research and innovation programme, Horizon 2020. The other half comes from large companies, mostly from the pharmaceutical sector; these do not receive any EU funding, but contribute to the projects 'in kind', for example by donating their researchers' time or providing access to research facilities or resources.

Most Popular Now

New AI Diagnostic can Predict COVID-19 w…

Researchers at King's College London, Massachusetts General Hospital and health science company ZOE have developed an artificial intelligence diagnostic that can predict whether someone is likely to have COVID-19 based...

Elsevier Adds to its Extensive Free Reso…

Elsevier, a global leader in information analytics specializing in science and health, is offering free access to a unique set of biomedical research tools and content to help researchers and...

Philips Launches HealthSuite Clinical Tr…

Royal Philips (NYSE: PHG, AEX: PHIA), a global leader in health technology, announced Clinical Trial Accelerator on Philips HealthSuite. This new tailored set of capabilities allows life science organizations to...

An EU Approach for Efficient Contact Tra…

EU Members States, supported by the Commission, have developed an EU toolbox for the use of mobile applications for contact tracing and warning in response to the coronavirus pandemic. This...

Biomax Provides AI-Based Semantic Search…

The bioinformatics company Biomax, headquartered in Planegg, Germany, makesitssemantic search platform AILANI available free of charge to research institutes around the world in order to support the rapid and successful...

COVID-19 and Health Tech: Building on th…

Highland Marketing's advisory board met to discuss the health tech response to the coronavirus outbreak. In many areas, this has been hugely impressive: but there are gaps, and there will...

InsurTech Hub Munich and dmac/Digital He…

InsurTech Hub Munich (ITHM) and dmac - Medical Valley Digital Health Application Center part of the Digital Health Hub Nuremberg/Erlangen announce a new cross-industry accelerator for the second half of...

Telemedicine Transforms Response to COVI…

A rapid increase in "virtual" visits during the COVID-19 pandemic could transform the way physicians provide care in the United States going forward, according to a new study led by...

Viveo Health Offers Free Telemedicine So…

Viveo Health, a global e-Health innovator, is making its 'Virtual Office for Doctors' platform free of charge to doctors and other medical professionals worldwide in light of the surge in...

Supercomputer Simulations Present Potent…

Several drugs approved for treating hepatitis C viral infection were identified as potential candidates against COVID-19, a new disease caused by the SARS-CoV-2 coronavirus. This is the result of research...

The Dedalus Group, Participated by Ardia…

The Dedalus Group, a leading European company, and one of the worldwide main ones, active in clinical healthcare information systems to support clinical professionals and organizations in order to improve...

The COVID-19 pandemic reveals the potent…

Two new articles provide insights on the use of telehealth or virtual care in the age of COVID-19 and beyond, pointing to its value to not only prevent contagious diseases...