Siemens Healthineers Achieves Important Milestone in Quantifiable Tissue Analysis Using MR

Siemens HealthineersAt the ISMRM (International Society for Magnetic Resonance in Medicine) in Montreal, Canada, Siemens Healthineers is the first supplier in the world to offer magnetic resonance fingerprinting (MRF) as a product for tissue analysis in clinical neurological research. The MRF application is the result of an exclusive, multi-year research partnership with Case Western Reserve University and the University Hospitals in Cleveland, which aims to make MR measurements much more quantifiable and reproducible. Thanks to this approach, a reliable judgment will be possible as to whether tissue is healthy or how badly it is damaged. This is a further means by which Siemens Healthineers is paving the way to personalized treatment and precision medicine. The MRF application and the associated database will initially be made available for the 3-Tesla Magnetom Vida magnetic resonance imaging system. Corresponding software packages for other 3T scanners from Siemens Healthineers will follow.

"MRF represents a paradigm shift in MR image acquisition," says Arthur Kaindl, head of Magnetic Resonance at Siemens Healthineers. "We generate unique ‘fingerprints’ that reflect the properties of the scanned tissue, and so we can describe the target anatomy numerically instead of visually for the first time. This information forms the basis for machine-assisted analysis for tissue classification, and thus also personalized treatment programs. The data also offers excellent opportunities for utilization and further development of artificial intelligence and Deep Learning."

Jeffrey Sunshine, Chief Medical Information Officer at the Cleveland University Hospitals and interim Co-Chair of Radiology at Case Western Reserve University and the University Hospitals adds: "I firmly believe that MRF will revolutionize the world of MR imaging. MRF lets us perform reliable tissue analyses. For example, we can assist tumor staging in cancer cases, which can save the patient from undergoing a biopsy and thus a surgical intervention. At the same time, the fact that tissue analyses are comparable means we can perform reliable progress checks."

The MRF method

MRF measures signal evolutions within each recorded voxel. The parameters for image acquisition are pseudo-randomized in the process, and the changes in signal are recorded. An algorithm compares the acquired datasets against a previously established database and locates the entry that most closely matches the signal evolution in question. This information can be compared to the fingerprints used in forensic investigations. Just like fingerprints, evaluation is possible only with access to a database that’s as comprehensive as possible. The forensic database links the fingerprint, and its unique characteristics, with the person’s own features (name, height, eye color, etc.). Likewise, the MRF database contains T1 and T2 values and can later be complemented with other parameters like relative spin density, B0, and diffusion. The clinic can link this information to the data for the underlying tissue type (bone, healthy tissue, diseased tissue).

MR images provide excellent information for diagnostics. But the images can differ greatly depending on the system, patient, and user, and are limited in terms of reproducibility and comparability. Although it has previously been possible to obtain absolute measurements of individual tissue properties, like diffusion, fat and iron deposits, perfusion, and relaxation times, lengthy measurement times were necessary. The previous deficits are comprehensively addressed by the new MRF method.

Magnetic Resonance Fingerprinting is currently under development and not commercially available. It is not for sale. Its future availability cannot be guaranteed.

About Siemens Healthineers

Siemens Healthineers enables healthcare providers worldwide to increase value by empowering them on their journey towards expanding precision medicine, transforming care delivery, improving patient experience and digitalizing healthcare. A leader in medical technology, Siemens Healthineers is constantly innovating its portfolio of products and services in its core areas of diagnostic and therapeutic imaging and in laboratory diagnostics and molecular medicine. Siemens Healthineers is also actively developing its digital health services and enterprise services. In fiscal 2018, which ended on September 30, 2018, Siemens Healthineers generated revenue of €13.4 billion and adjusted profit of €2.3 billion and has about 50,000 employees worldwide.

Most Popular Now

Sanofi and Google to Develop New Healthc…

Sanofi and Google will establish a new virtual Innovation Lab with the ambition to radically transform how future medicines and health services are delivered by tapping into the power of...

A Miniature Robot that could Check Colon…

Engineers have shown it is technically possible to guide a tiny robotic capsule inside the colon to take micro-ultrasound images. Known as a Sonopill, the device could one day replace...

Call for Startup Pitch Day @ Villeroy …

The Startup Pitch Day is a competition to identify innovative Startups with the aim of creating potential cooperation with Villeroy & Boch Innovations GmbH. Therefore 10 startups are invited to...

Oxford Health Uses Oxehealth Technology …

Oxford Health NHS Foundation Trust has introduced a new observation protocol for checking the safety of patients with severe mental health conditions at night, after a formal evaluation of technology...

Wearable Technology to Personalize Lu-17…

Researchers at the University of Washington in Seattle, Washington, are developing a user-friendly (worn at home) vest with technology that collects data to tailor personalized therapy for patients with metastatic...

3D Body Mapping could Identify, Treat Or…

Medical advancements can come at a physical cost. Often following diagnosis and treatment for cancer and other diseases, patients' organs and cells can remain healed but damaged from the medical...

QUIBIM to Develop Platform in Leading Re…

QUIBIM is helping to advance knowledge of the most lethal pediatric tumors through EU-funded project PRIMAGE, which exploits precision information from medical imaging to establish tumor prognosis, and expected treatment...

MEDICA App COMPETITION 2019 Launches

18 - 21 November 2019, Düsseldorf, Germany. Held in Düsseldorf, the world's leading medical trade fair, MEDICA, is also the world’s number 1 when it comes to start-ups in the health...

Siemens Healthineers, the University of …

Siemens Healthineers, University of Missouri System (UM System) and University of Missouri Health Care (MU Health Care) launch "Alliance for Precision Health." The ten-year collaboration will bring the partners' expertise...

Consumers Less Attentive to News Content…

Heart rate variability decreases and changes in sweat are muted when viewing video news content on smaller screens. Both are indications of reduced attentiveness and engagement with content, according to...

Advanced Therapies Feature in New IMI Ca…

Advanced therapies are a major part of new Innovative Medicines Initiative (IMI) Calls for proposals. The two advanced therapies topics aim to accelerate research into advanced therapies for rare diseases...